ACE2 is expressed by epithelial cells of the lungs at a high level, a major target of the disease, SARS-CoV-2 infects ACE2-expressing cells in the lung, blocking ACE2 interaction with the S protein of SARS-CoV-2 to curtail SARS-CoV-2 infection are becoming very attractive therapeutics potential for treatment and prevention of COVID-19, thus, we could target this interaction site with small molecules [9]. Here, ACE2 is linked to COVID-19.