Oroxylin A regulates the vascular tone by inhibiting vascular hyporeactivity caused by NO overproduction and reverses the endothelial barrier dysfunction and inflammation by inhibiting the IRAK-4-mediated IKKα/β phosphorylation, suggesting that Oroxylin A administration as a potentially useful therapeutic approach for clinical interventions in septic shock [38]. This evidence concerns the gene IRAK4 and Shock.