BACE1 and cancer: Faghihi et al., for example, found that an anti-sense RNA can bind to BACE1 mRNA, competitively inhibiting the negative regulation of BACE1 by miRNA [21]; (2) to regulate target genes by forming pre-miRNAs after RNA splicing and producing specific miRNAs [22, 23]; and (3) to act as endogenous miRNA sponge to suppress miRNA function, so as to affect malignant biological behavior of cancer cells [24].