We also evaluated the expression of downstream functional proteins of Wnt pathway, E-cadherin, C-myc, CyclinD1, and MMP-9, in HCC, in metastasis and adjacent tissue (p < 0.01), and we observed that protein levels were significantly higher in HCC metastasis than in primary HCC (p < 0.05). Here, CCND1 is linked to hepatocellular carcinoma.