Some studies have shown that ASOs can target (GGGGCC)n without lowering the mRNA level of C9orf72 mRNA, significantly reducing the number of RNA foci and the percentage of cells containing RNA foci in each cell in induced pluripotent stem cells (iPSCs) from C9orf72 ALS patients (Donnelly et al., 2013). This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.