Results showed that those genes relevant to risk score were mainly enriched in keratinocyte differentiation, and RHO GTPases activate PNKs, epithelial tube morphogenesis, establishment or maintenance of cell polarity, etc. Interestingly, we compared pathways predicted with annotations of these six RBPs in GeneCards6 and found that HSPG2 acted as an anti-angiogenic and anti-tumor peptide that inhibited endothelial cell migration and collagen-induced endothelial tube morphogenesis. This evidence concerns the gene HSPG2 and neoplasm.