Results of enrichment analysis showed that genes were mostly enriched in keratinocyte differentiation, and RHO GTPases activate PNKs, epithelial tube morphogenesis, establishment or maintenance of cell polarity, and so on, suggesting that these pathways were correlated with the disease progression of BLCA with high-risk score (Figures 9B,C). The gene discussed is RHO; the disease is bladder transitional cell carcinoma.