BTK and fungal infectious disease: Considering the relevance of understanding the mechanism by which BTK inhibition impairs immune response, we sought to determine the effects of ibrutinib and acalabrutinib on the macrophage/monocyte population in CLL during a fungal infection by A. fumigatus. We demonstrate that BTK inhibition upon exposure to ibrutinib and acalabrutinib significantly hampered the inflammatory response of NLC during A. fumigatus infection.