The administration of autologous CD4+CD25highCD127low Tregs, which were isolated from the peripheral blood of the same individual and expanded ex vivo under polyclonal stimulation, to children with recent-onset of type 1 diabetes, dramatically increased C-peptide levels and decreased the dependency on exogenous insulin, demonstrating a safe and efficient therapy for T1D (105, 106). Here, CD4 is linked to type 1 diabetes mellitus.