This was reported for a number of tumor-associated antigens such as Ep-CAM for colon carcinoma, HER2/neu for breast carcinoma, EGFR for epithelial, colorectal and renal cell carcinoma, HLA class II, CD20 and CD30 for B-cell lymphoma, and carcinoembryonic antigen as shown in in vitro studies (127, 128, 238–242). The gene discussed is ERBB2; the disease is breast carcinoma.