To gain a better mechanistic insight into the cardioprotective effects of RvE1 in mice with polymicrobial sepsis, we investigated the effects of RvE1 treatment on the cardiac phosphorylation of Akt on Ser473, phosphorylation of IKKα/β on Ser176/180, subsequent nuclear translocation of p65 NF-κB, and phosphorylation of ERK1/2 on Tyr202 and Tyr204 and JNK1/2 on Thr183 and Thr185. Here, AKT1 is linked to Sepsis.