As respect to pathological features, combined glomerular C4c and IgM, and interstitial inflammation were significantly associated with the development of DKD (HR 0.704, 95% CI [0.509, 0.973], p = 0.033; HR 1.946, 95% CI [1.102–3.435], p = 0.022; respectively). Here, CD40LG is linked to diabetic kidney disease.