Ziegler et al. recently demonstrated that HIV-1 viral infection of stimulated CD4+ T-cells induced a significant shift toward presentation of longer HLA-I peptides (49) and several years ago it has been shown by Yaciuk et al. that epitopes as long as 20 amino acids were eluted from HLA-A*11:01 HIV-1 infected CD4+ T cells (51). The gene discussed is CD4; the disease is viral infectious disease.