As shown in Figures 7A–C, upregulation of NEAT1 promoted migration and invasion of HFLS-RA cells (both p < 0.0001), while downregulation of NETA1 suppressed migration and invasion of HFLS-RA cells (p < 0.0001 and p < 0.001, respectively). This evidence concerns the gene NEAT1 and rheumatoid arthritis.