NEAT1 and rheumatoid arthritis: As shown in Figures 2A,B, NEAT1 was overexpressed using the pcDNA-NEAT1 construct in HFLS-RA cells (p = 0.0116); we used three siRNAs against NEAT1 to downregulate NEAT1 (p = 0.0002, p = 0.0006, and p = 0.09, respectively), and siRNA#1 and siRNA #2 were selected for further analysis.