CSF1R and neoplasm: BLZ-945 in combination with cyclophosphamide and topotecan inhibited neuroblastoma growth and improved survival in subcutaneous and intra-renal neuroblastoma tumors in immunodeficient NSG or NOD/SCID mice, suggesting that CSF-1R blockade with chemotherapy might be effective in patients with neuroblastoma and restricted anti-tumor T cell responses (122).