TAMs can promote immunosuppression in the tumor microenvironment by (1) suppressing the cytotoxic and metabolic activity of NK cells; (2) expanding Treg cells which indirectly suppress the function of effector T cells; (3) interacting with cytotoxic T cells in antigen-specific and antigen non-specific manners; and (4) stimulating MDSCs to secrete IL-10 which inhibits innate and adaptive immune responses. Here, IL10 is linked to neoplasm.