A recent study has shown that the presence of TAMs facilitated up-regulation of MYC protein expression through the signal transducer and activator of transcription 3 (STAT3) pathway in non-MYCN-amplified neuroblastoma tumor cells, suggesting this may at least partially explain the finding that TAMs are associated with poor survival in non-MYCN amplified tumors (67). The gene discussed is STAT3; the disease is neoplasm.