A study of 102 non-MYCN-amplified neuroblastoma tumors demonstrated that these tumors express high level of inflammation-related genes expressed by M2 macrophages and identified a gene signature that consists of IL-6, IL-6 receptor (IL-6R), IL-10, and TGFβ and is associated with significantly worse prognosis (50). The gene discussed is TGFB1; the disease is neuroblastoma.