BRD4 and neuroblastoma: We have recently shown that BRD4 promotes polarization of macrophages into anti-inflammatory phenotype and treatment with bromodomain inhibitor JQ1 or dual PI3K/BRD4 inhibitor SF1126 or SF2523 blocks immunosuppression and promotes adaptive immune responses in solid tumors including neuroblastoma (131, 134, 135, 155, 156).