Overall, we saw a shift toward double-positive PD1+LAG-3+ and PD1+TIM-3+ and single-positive PD1−LAG-3+ and PD1−TIM-3+ cells in the CD8+ T cell subset of COVID-19 patients whereas in malaria, the distribution changed more toward double-positive PD1+LAG-3+ and PD1+TIM-3+ and single-positive PD1+LAG-3− and PD1+TIM-3− T cells. The gene discussed is CD8A; the disease is malaria.