Missense mutations of serine p.S208 or p.S242 in MEFV cause a different phenotype that presents with recurrent episodes of neutrophilic dermatosis, fever, elevated acute-phase reactants, arthralgia, myalgia/myositis, an autosomal dominant disease that was termed pyrin-associated auto-inflammation with neutrophilic dermatosis (PAAND) (72). This evidence concerns the gene MEFV and myositis disease.