NLRP3 and Muckle-Wells syndrome: Autosomal-dominant, heterozygous GOF mutations in NLRP3 cause the disease-severity spectrum of the predominantly familial cold induced autoinflammatory syndrome (FCAS), Muckle Wells syndrome (MWS), and the mostly sporadic severe phenotype Neonatal-onset Multisystem Inflammatory Disease (NOMID) (Figure 2A).