Several other recent studies that followed also reported variants in the POLR3A gene as being responsible for causing hypomyelination, hypodontia and hypogonadotropic hypogonadism, thus establishing a series of POLR3A gene variants to be associated with polymerase III-related leukodystrophy (139–144). This evidence concerns the gene POLR3A and hypogonadotropic hypogonadism.