CHD7 is the gene that codes for the chromodomain helicase DNA binding protein 7 and variants found in the AD form were first reported as the genetic cause in a series of patients with CHARGE (coloboma, heart defect, atresia choanae, growth retardation, genital abnormality, and ear abnormality) syndrome (57, 120). This evidence concerns the gene CHD7 and Abnormality of the ear.