In a more prolonged uremic condition using a diet with adenine plus high-phosphorus for 14 days to induce CKD, which resulted in high levels of Fgf23 mRNA and serum FGF23 in rats, an oral gavage intervention with PD173074 given during the last 2 days of treatment reduced FGF23 induction by 75% in calvaria and completely normalized circulating FGF23 (33). Here, FGF23 is linked to chronic kidney disease.