The change in insulin levels from the beginning of exercise (time 120) to the end of exercise (time 165) had a study day by group interaction (P = 0.03), such that non-obese individuals (39.2 ± 8.1 μU/mL) had less of a drop during PMEX compared to T2D (109.7 ± 30.1 μU/mL; P < 0.05) and tended to have less of a drop compared to obese (102.3 ± 22.6 μU/mL; P = 0.06). This evidence concerns the gene INS and type 2 diabetes mellitus.