Bogardus et al. (43) and Coker et al. (49) both showed that weight loss can improve hepatic glucose metabolism in patients with T2D, while Petersen et al. (58) also observed that a body weight loss of 8 kg lowered fasting glucose and insulin concentrations in patients with T2D, in addition to lowering fasting EGP and improving insulin-mediated suppression of EGP. The gene discussed is INS; the disease is type 2 diabetes mellitus.