Deregulated TGFβ has also been shown to epigenetically induce Klotho deficiency and renal fibrosis in mice via induction of a number of miRNAs, including miR-21, miR-192, miR-491, miR-382, miR-377, miR-214, and miR-433 (82). This evidence concerns the gene TGFB1 and renal fibrosis.