Numerous studies have shown that similarly to animals overexpressing α-Klotho, administration of the peptide also improved renal fibrosis in UUO and bilateral IRI models (10, 120, 121, 135, 148, 149), cardiac fibrosis in mice following induced injury (10), and could reduce acute to chronic disease progression with development of post AKI-cardiomyopathy. Here, KL is linked to renal fibrosis.