Mice deficient in Klotho exhibit a phosphate imbalance and hyperphosphatemia due to impaired urinary phosphate excretion, but significantly develop a complex progeric phenotype including poor growth, atrophy of multiple organs, vascular calcification (VC), sarcopenia, cardiac hypertrophy and fibrosis, cognitive impairment, and shortened lifespan (1, 2, 5). This evidence concerns the gene KL and hyperphosphatemia.