As the result of the CRC-SCA natural history study, we found that the rates of disease progression of SCA1, SCA2, SCA3, and SCA6 (annual increase in SARA by 1.61, 0.71, 0.65, and 0.87 points, respectively) (12) are consistent with those in EUROSCA (15). Here, ATXN3 is linked to colorectal carcinoma.