CACNA1G and essential tremor: As for animal experiments, lack of 4–10 Hz rhythmic burst discharges in inferior olive (IO), a crucial promoter for essential tremor, was present in mice lacking the CaV3.1 gene (73), and five T-type calcium antagonists, including ethosuximide and zonisamide, suppressed tremor in two different animal tremor models (74), suggesting that LVA Ca2+ channels are the molecular pacemaker substrates for intrinsic neuronal oscillations of IO neurons, and this mechanism is likely to be a pathological cause of essential tremor (Figure 2).