PPARG and arteriosclerosis: In obese people, elevated miR-27 levels in the blood have been associated with higher TG and LDL-C levels and lower HDL-C levels (Can et al., 2016); moreover, it has been suggested that miR-27b can accelerate the development of arteriosclerosis by reducing the expression of PPARγ, thereby inducing perivascular adipose tissue hypertrophy (Chen et al., 2012).