However, in different experimental models of mice and rats with glomerular disease, increased glomerular desmin staining is recognized as a marker of podocyte dedifferentiation and injury (Crowley et al., 2009; Casare et al., 2016; Xie et al., 2019) and is followed by decreased nuclear WT1 expression and loss of slit diaphragm proteins (Greka and Mundel, 2012). This evidence concerns the gene WT1 and glomerular disorder.