However, in different experimental models of mice and rats with glomerular disease, increased glomerular desmin staining is recognized as a marker of podocyte dedifferentiation and injury (Crowley et al., 2009; Casare et al., 2016; Xie et al., 2019) and is followed by decreased nuclear WT1 expression and loss of slit diaphragm proteins (Greka and Mundel, 2012). The gene discussed is DES; the disease is glomerular disorder.