Notably, proximal tubule cells express kidney injury molecule 1 (Kim-1), which is highly upregulated after acute kidney injury (Ichimura et al., 1998; Sabbisetti et al., 2014), acts as a marker of cell differentiation and proliferation (Han et al., 2002), and mediates the phagocytosis of oxidized lipids and apoptotic bodies, including luminal cellular debris (Ichimura et al., 2008). The gene discussed is HAVCR1; the disease is acute kidney injury.