Similarly, resveratrol, but not another putative SirT1 agonist SRT1720, prevented the development of TAA in Fbn1C1041G/+ mice, a model of Marfan’s syndrome, by stimulating an endothelial cell-derived factor, which downregulated miR-29b and upregulated Bcl-2 in VSM cells, inhibiting their apoptosis (Hibender et al., 2016). The gene discussed is SIRT1; the disease is Marfan syndrome.