SIRT1 and Aortic dissection: Taken together, these well-established anti-oxidant effects of SirT1 are consistent with the findings that VSM-specific SirT1 deletions in mice, and decreased expression of SirT1 in human aorta, are associated with aortic dissection or aneurysms (Fry et al., 2015; Chen et al., 2016).