HMOX1 and cardiovascular disorder: Dietary anti-oxidants (Abraham and Kappas, 2005; Moran et al., 2017; Hou et al., 2019) and clinically widely used compounds, such us statins, have shown favorable pleiotropic effects partly mediated by HO-1 induction (Lee et al., 2004; Piechota-Polanczyk et al., 2018) or SirT1 expression (Strycharz et al., 2018), providing a strong rationale for their therapeutic benefits in cardiovascular diseases, including AA (Hou et al., 2019).