More recently, we found that H2O2, as well as TGF-β1, a pro-fibrotic cytokine known to be activated in Marfan’s syndrome and to upregulate Nox4 in the vasculature (Lu et al., 2016; Siu et al., 2017; Zuniga-Munoz et al., 2017; Jimenez-Altayo et al., 2018), increases the reversible oxidation of SirT1 in aortic VSM cells (E. Budbazar and F. Seta, unpublished results). Here, SIRT1 is linked to Marfan syndrome.