Resveratrol, a grape-derived non-toxic polyphenol known to activate SirT1, decreases the incidence of AAA in angII-infused apoE–/– mice fed a high fat diet by increasing ACE2 and downregulating NF-kB, Akt, ERK1/2 and ATR1 in human aortic VSM (Moran et al., 2017). This evidence concerns the gene SIRT1 and triple-A syndrome.