ACE and hypertensive disorder: Conversely, the pharmacological blockade of either angiotensin converting enzyme (ACE) or angiotensin II (AngII) type 1 (AT1) receptor during late nephrogenesis (postnatal days 2–14) impair renal maturation and is associated with the development of hypertension later in life (Loria et al., 2007; Saez et al., 2007).