These genes present significant statistical enrichment for the following pathways: Pentose phosphate pathway, Glycine, serine and threonine metabolism, amino acid biosynthesis, and carbon metabolism, all of them related to essential metabolism, as well as to primary immunodeficiencies, renin-angiotensinogen system, neuroactive ligand-receptor interaction related to immune signaling and inflammation, and to cell cycle processes, such as the mRNA surveillance pathway, RNA transport, and ribosome biogenesis in eukaryotes. The gene discussed is REN; the disease is inborn error of immunity.