HAS3 is the most active enzyme of the HAS family and polymerizes shorter HA chains (Itano et al., 1999; Itano and Kimata, 2002) that stimulates cell signaling, proliferation, and epithelial-to-mesenchymal transition in cancer models (Kultti et al., 2014; Kuo et al., 2017; Arasu et al., 2019). Here, HAS3 is linked to cancer.