Blockade of L-SIGN has shown promise in reducing colon cancer metastasis in murine models (Zuo et al., 2013; Na et al., 2017), whilst MR has been suggested as a potential target for treating hepatic metastases and increasing anti-tumour cytotoxicity (Arteta et al., 2010). The gene discussed is CLEC4M; the disease is malignant colon neoplasm.