As reviewed in Rayburn et al. (2005), Mdm2 is overexpressed in liposarcomas, osteosarcomas, testicular germ cell tumors, embryonic carcinomas, brain tumors (including glioblastomas and astrocytomas), hematological malignancies, bladder cancer, breast cancer, colorectal cancer among others. The gene discussed is MDM2; the disease is osteosarcoma.