CCN2 and Myocardial fibrosis: Collectively, the results of present study suggest that 8 weeks of EA at PC6 inhibited myocardial fibrosis in SHRs, which might be mediated by downregulation of an enhanced Ang II -TGF-β1-CTGF/TNF-α pathway as well as upregulation of the diminished expression of MMP-9.