The myocardial fibrosis can be myocyte death, inflammation, enhanced workload, or hypertrophy and is often aggravated by the renin-angiotensin system (RAS), cytokines (TNF-α), growth factors (such as TGF-β1 and CTGF), and matricellular proteins. This evidence concerns the gene TGFB1 and Myocardial fibrosis.