In conclusion, the present CDDP-crosslinked DOX-loaded HA micelles prepared with innocuous methods and possessed an outstanding ability to control the release of DOX and CDDP for pH sensitivity and CD44 targeting.HA-DOX-CDDP exhibited synergistic anticancer effects, tumor-targeted ability, and reduced multi-organ toxicity compared with conventional anti-breast cancer agents. Here, CD44 is linked to neoplasm.