APOE and atherosclerosis: Furthermore, MEK-inhibition also has antiatherogenic properties as MEK-inhibition combined with activation of liver X receptor (LXR) significantly inhibited the development of atherosclerosis in ApoE deficient (ApoE-/-) mice through reverse cholesterol transport and by blocking the formation of foam cells (Chen et al., 2015; Li X. J. et al., 2016; Zhang et al., 2016).