GLO1 and type 1 diabetes mellitus: Therefore, this study aims to examine the antidepressant- and anxiolytic-like effects of hesperidin in rats with type 1 diabetes, to investigate the induction of Glo-1 by hesperidin in the brains of diabetic rats, and to clarify the critical role of the Nrf2/ARE pathway in the enhancement of Glo-1 and the antidepressant and anxiolytic effects of hesperidin.