Evidence verifies that the induction of Glo-1 leads to clear prophylactic and therapeutic effects on diabetic complications (Maher et al., 2011; Jack et al., 2012; Skapare et al., 2012; Liu et al., 2013b; Rabbani and Thornalley, 2014), including diabetic encephalopathy (Liu et al., 2013a; Liu et al., 2017b; Zhu et al., 2018). This evidence concerns the gene GLO1 and diabetic encephalopathy.