More recently, dietary supplementation of ACNs from Korean black beans to the APP/PS1 mouse model of AD demonstrated that ACNs reduce oxidative stress induced by Aβ aggregation by activation of the p-PI3K/Akt/GSK3β pathway, which has been found to promote nuclear translocation of Nrf2 and the activation of HO-1 and glutathione cysteine ligase modulatory subunit (GCLM) target genes. The gene discussed is APP; the disease is Alzheimer disease.