GPT and leukemia: ACN extract of roselle (Hibiscus ACNs) was supplemented in the diet of the rat model of N-methyl-N-nitrosourea (NMU) -induced leukemia, and it significantly reduced the elevated aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in serum and blood, and prevented NMU-induced leukemic cell infiltration and subsequent tissue damage (Tsai et al., 2014).