ACNs significantly inhibited the migration and cell invasion, lowered the migration distance of HER-2 positive human breast cancer cells, phosphorylation of cSrc, FAK, and p130C, lowered the levels of mesenchymal markers (fibronectin, vimentin), decreased the interaction between HER-2 and FAK, FAK and cSrc, and inhibited the epithelial-mesenchymal transition (Zhou et al., 2017). Here, PTK2 is linked to breast carcinoma.