In CF airway epithelial cells, the morphology and functions of mitochondria, the main cellular component involved in ROS production (Favia et al., 2019) are altered (Feigal et al., 1982; Von Ruecker et al., 1984; Antigny et al., 2009) and restored by correction of F508del CFTR mutation (Valdivieso et al., 2007; Taminelli et al., 2008; Valdivieso et al., 2012; Atlante et al., 2016). Here, CFTR is linked to cystic fibrosis.