CFTR and cystic fibrosis: The activity of phospholipase A2 (PLA2), which releases AA from the membrane phospholipids and can interact with CFTR, is increased in human CF bronchial epithelial cells and in CFTR-knockout mice (Miele et al., 1997; Six and Dennis, 2000; Ghosh et al., 2006; Borot et al., 2009; Dif et al., 2010).