IL6 and cystic fibrosis: Although, not a direct demonstration of SPMs’ impact on cytokine secretion, it is worth noting that human studies reveal that the levels of pro-inflammatory cytokines (IL-6 and IL-8) are inversely correlated with LXA4 and RvD1 in the sputum of patients with CF (Chiron et al., 2008; Ringholz et al., 2014; Eickmeier et al., 2017; Isopi et al., 2020).