In prevention studies, oral administration of Ang-(1–7) improved body mass, adiposity index, plasma triglycerides levels, glucose tolerance, insulin sensitivity in rats and mice fed with HF (Oliveira Andrade et al., 2014; Williams et al., 2016) and fructose (Giani et al., 2009; Muñoz et al., 2012) diets. This evidence concerns the gene INS and hydrops fetalis.