In addition, Ang-(1–7) increased Mas and AKT liver mRNA gene expression while A-1317 increased both, Mas and MRGD, and AMPK. Taken together, our data showed that treatment with A-1317 was able to ameliorate MetS disorder probably by Mas and MRGD via activation of AMPK and increasing pancreatic β cell function. This evidence concerns the gene MAS1 and metabolic syndrome.