These data suggest that although both Ang-(1–7) and A-1317 act on the ECA2/Ang-(1–7)/Mas axis, A-1317 has affinity for both Mas and MRGD, but this new compound, acts preferentially via AMPK, while Ang-(1–7) appears to act primarily on Mas via AKT in MetS rats. The gene discussed is MAS1; the disease is metabolic syndrome.