A number of cytokines and their signaling pathways have been shown to regulate EMT, such as transforming growth factor-β (TGF-β), Wnts, Notch, fibroblast growth factors (FGFs) and bone morphogenetic protein (BMP), etc. Preventing EMT will increase significantly the drug sensitivity of tumor cells and the survival rate of human CRC patients (Ren et al., 2013; Fischer et al., 2015; Zheng et al., 2015). This evidence concerns the gene TGFB1 and neoplasm.