PLA2G4A and cancer: The eicosanoid pathway in cancer has been reviewed in detail (Panigrahy et al., 2010; Wang and DuBois, 2010; Gomes et al., 2018; Umamaheswaran et al., 2018); briefly, arachidonic acid (AA) is liberated from membrane phospholipids by phospholipase A2 (PLA2) and metabolized by one of three pathways cyclooxygenase (COX), lipoxygenase (LOX) and P450 epoxygenase which then produce a wide range of prostanoids, leukotrienes, epoxyeicosatrienoic acids (EETs), and hydroxyeicosatetraenoic acids (HETEs) (Wang and DuBois, 2010; Gomes et al., 2018).