Alexanian and colleagues have shown that CYP4A/4F genes were increased in ovarian cancer tissue compared to normal tissues and further more CYP4F2 protein and 20-HETE were also higher in ovarian cancer samples (Alexanian et al., 2012) thus demonstrating a potential role for 20-HETE in ovarian cancer which warrant additional mechanistic studies for this pathway. The gene discussed is CYP4F2; the disease is ovarian cancer.