In addition, the expression of collagen I (Col1a1) and Ras-related protein Rap1b decreased in the model group, which could be improved by YQHYJD (Figure S3), Col1a1 and Rap1b proteins belong to Platelet activation pathway In KEGG pathways (Figure 5), suggesting that YQHYJD may promote platelet activation, so as to improve the hypercoagulable state of blood in the lungs of animals with ARDS. Here, RAP1B is linked to acute respiratory distress syndrome.