One of these BET inhibitors, JQ1, is associated with high specificity for Brd4 inhibition and has been shown to exert protective effect in several diseases, including arthritis, heart remodeling, Alzheimer’s disease and stroke (Spiltoir et al., 2013; Benito et al., 2017; An et al., 2018; Demars et al., 2019). This evidence concerns the gene BRD4 and early-onset autosomal dominant Alzheimer disease.