BRD4 and arthritic joint disease: One of these BET inhibitors, JQ1, is associated with high specificity for Brd4 inhibition and has been shown to exert protective effect in several diseases, including arthritis, heart remodeling, Alzheimer’s disease and stroke (Spiltoir et al., 2013; Benito et al., 2017; An et al., 2018; Demars et al., 2019).