Clinical evidence supports increased methyl donor S-adenosylmethionine in the brains of patients with schizophrenia (Guidotti et al., 2007), and an association between hypermethylation of the RELN promoter (Grayson et al., 2006) and down-regulation of the corresponding protein (Reelin) in the brains of these patients (Guidotti et al., 2016). The gene discussed is RELN; the disease is schizophrenia.