The siRNA-based LRRTM3 knockdown in SH-SY5Y human neuroblastoma cells reduces Aβ secretion and the production of the intracellular C-terminal fragments (CTFs) by β-secretase (βCTF), suggesting that LRRTM3 positively modulates BACE1 processing of APP (Figure 3). The gene discussed is LRRTM3; the disease is neuroblastoma.