To further validate whether Aβ-insensitive synaptic organizers such as LAR-RPTPs and TrkC have a protective role against Aβ in AD synapses, it would be worth testing whether their KO in AD model mouse brain accelerates synaptic pathology and/or if their overexpression in AD model mouse brain decelerates synaptic pathology. The gene discussed is NTRK3; the disease is Alzheimer disease.