To further validate whether Aβ-insensitive synaptic organizers such as LAR-RPTPs and TrkC have a protective role against Aβ in AD synapses, it would be worth testing whether their KO in AD model mouse brain accelerates synaptic pathology and/or if their overexpression in AD model mouse brain decelerates synaptic pathology. This evidence concerns the gene PTPRF and Alzheimer disease.