MAPT and Alzheimer disease: There are two major pathohistological hallmarks of the AD brain: extracellular senile plaques and intracellular neurofibrillary tangles (NFT), the major constituents of which are amyloid β (Aβ) peptides and hyper-phosphorylated tau proteins, respectively (Ballard et al., 2011; DeTure and Dickson, 2019).