NTRK3 and Alzheimer disease: Given that NT-3 enhances PTPσ-TrkC interaction and their synaptogenic activity (Ammendrup-Johnsen et al., 2015; Han et al., 2016b), it has also been suggested that for synapse maintenance in AD, NT-3 might reinforce PTPσ-TrkC complex to increase synaptic tolerance to Aβ.