To establish whether the P2X7 receptor impacts on the miRNA expression profile in the brain, ipsilateral hippocampi from wt and P2rx7−/− mice were analyzed under physiological conditions (vehicle-injected control mice) and post-status epilepticus using a genome-wide high-throughput qPCR-based miRNA platform (OpenArray; n = 3 per group, each sample was a pool of two hippocampi from different mice). The gene discussed is P2RX7; the disease is status epilepticus.