Genes involved in the regulation of the immune system (e.g., “Antigen processing: Ubiquitination and Proteasome degradation,” “Class I MHC mediated antigen processing and presentation,” “Cytokine Signalling in Immune system”) are overrepresented in P2X7 receptor-dependent up- and down-regulated miRNAs in vehicle-injected control mice and post-status epilepticus, in line with the P2X7 receptor being a major contributor to inflammatory signaling cascades (Di Virgilio et al., 2017). This evidence concerns the gene P2RX7 and status epilepticus.