While the P2X7 receptor has been described to be mainly expressed on microglia and oligodendrocytes during physiological conditions (Collo et al., 1997; Matute et al., 2007; Kaczmarek-Hajek et al., 2018), the P2X7 receptor has also been found on neurons following status epilepticus and during epilepsy (Doná et al., 2009; Engel et al., 2012; Jimenez-Pacheco et al., 2016). The gene discussed is P2RX7; the disease is epilepsy.