Indeed, IL-33 plays a double-edged sword in a variety of diseases, such as intracerebral hemorrhage (ICH) (Gao et al., 2017b), traumatic brain injury (TBI) (Gao et al., 2018) and central multiple sclerosis (MS) (Jafarzadeh et al., 2016). Here, IL33 is linked to myeloid sarcoma.