On the other hand, the cytokines secreted by activated microglia, including TNF-α, interleukin 1β (IL-1β), and IL-6, are associated with neurodegeneration predominantly in atypical parkinsonism disorders, such as PSP and MSA (van Olst et al., 2020). This evidence concerns the gene IL6 and supranuclear palsy, progressive, 1.