TH and hypothyroidism: Since glial lineage commitment occurs in the absence of TH signaling (Remaud et al., 2017), transient methimazole-induced hypothyroidism during the last 4 weeks of a 6-week cuprizone diet in adult mice, when new OPCs are proliferating to participate to myelin repair (Picard-Riera et al., 2002), enhanced SVZ-OPC generation.