A potential pro-regenerative function of T3 or other TH signaling components in AD-accompanied (hippocampal) neurodegeneration still awaits more proof-of-concepts, but deserves further testing in appropriate models given their strong role in AHN in the brain, and the persistence of hippocampal neurogenesis in aged healthy and AD individuals (Moreno-Jiménez et al., 2019; Tobin et al., 2019). The gene discussed is TH; the disease is Alzheimer disease.