Adult-onset hypothyroidism in rodents does not change the proliferative activity of type 1 SGZ-NSCs (Desouza et al., 2005; Kapoor et al., 2012; Sánchez-Huerta et al., 2016), nor does it change in TRα1–/– and TRα2–/– mice lacking and overexpressing TRα1, respectively (Kapoor et al., 2010), suggesting they are not responsive to TH. The gene discussed is TH; the disease is hypothyroidism.