Given that (i) TH has consistent effects on oligodendrocyte differentiation and remyelination in animal models of MS, (ii) SVZ-oligodendrogenesis is maintained throughout human life (Ernst et al., 2014; Weissleder et al., 2016) and (iii) SVZ-OPC generation increases upon MS-induced injury in humans (Nait-Oumesmar et al., 2007), we and others propose that there is strong potential for TH as a treatment in MS patients. Here, TH is linked to myeloid sarcoma.