MAPT and Alzheimer disease: Aβ, α-synuclein, tau and TDP-43 have been implicated in AD and other forms of dementia, as well as in PD (Paleologou et al., 2005; Finder and Glockshuber, 2007; Cook et al., 2008; Honson and Kuret, 2008; Guo et al., 2011; Herman et al., 2011; Jiang et al., 2016).