CD8A and Alzheimer disease: At a cut-off of log2 fold change >0.5 and padj less than 0.05, PBMCs had no differences in patterns of gene expression between AD and HC (0 DE genes), and only two genes each were differentially expressed in CD4 memory (GNAL and KIF18B) and CD8 memory (RPL10P6 and PRAM1) T cells (Figure 6C).