Specifically, we (i) compared the relative frequency of major PBMC cell subsets, (ii) characterized T cell responses to proteins involved in neurodegeneration such as Aβ, APP, tau, α-synuclein, TDP-43, PT, and Epstein-Barr virus and cytomegalovirus (EBV/CMV), (iii) correlated antigen-specific reactivity with demographic and clinical variables including age, gender, time since diagnosis and cognitive score, and (iv) conducted a transcriptomic analysis of PBMC, CD4 memory and CD8 memory T cells to assess differential expression of genes in AD compared to HC. Here, CD4 is linked to Alzheimer disease.