VHL and nonpapillary renal cell carcinoma: Significant difference (p-value < 0.05) in mutation frequencies between two populations was observed in 11 out of 84 driver genes, of which 3 were previously proposed SMGs in ccRCC [42], including VHL (p-value = 8.6E−4), PBRM1 (p-value = 8.4E−5) and KDM5C (p-value = 3.8E−2) (Table 2).