PBRM1 and nonpapillary renal cell carcinoma: PBRM1 is involved in the regulation of genes of metabolic pathways that is known to be essential for driving ccRCC, including the hypoxia response related PI3K signaling pathway [48], high percentage of wild type PBRM1 could be one reason why better treatment outcome of PI3K inhibitor was observed in the Chinese population (data not shown).