IL12 is required to induce a proinflammatory, TH1-like cytotoxic phenotype of T cells and actively induces atherosclerosis.58,59 Potentially, as a result of the My.3-specific IL12, we observed open chromatin at the IFNG and TNF loci in CD4.0, confirming its activated, cytotoxic phenotype and suggesting that this cluster has TH1-like properties (Figure VIIG and VIIH in the Data Supplement). This evidence concerns the gene CD40 and atherosclerosis.