CD4 and atherosclerosis: In contrast, murine scRNA-seq studies describe a more prominent presence of myeloid cells, which may be caused by the previously described declining myeloid content upon progression of human atherosclerotic plaques, whereas T cells reciprocally increase in human atherosclerosis.71,72 Both CD4+ and CD8+ T-cell subsets were characterized by their activation state, rather than classical TH or TC subclasses.