Such findings indicate that the aberrant activation of eIF4E, that is mainly observed in HPV‐positive cervical cancer cells, depends on the upregulation of the PI3K/AKT and MEK/ERK pathways on downstream effectors (4EBP1 and MNK1), thereby affecting the rate of translation of CCND1 and ODC1 mRNA. The gene discussed is AKT1; the disease is cervical carcinoma.